全文获取类型
收费全文 | 15203篇 |
免费 | 1036篇 |
国内免费 | 223篇 |
专业分类
耳鼻咽喉 | 220篇 |
儿科学 | 345篇 |
妇产科学 | 738篇 |
基础医学 | 1934篇 |
口腔科学 | 275篇 |
临床医学 | 1613篇 |
内科学 | 3210篇 |
皮肤病学 | 375篇 |
神经病学 | 929篇 |
特种医学 | 561篇 |
外科学 | 2334篇 |
综合类 | 434篇 |
现状与发展 | 2篇 |
一般理论 | 3篇 |
预防医学 | 721篇 |
眼科学 | 287篇 |
药学 | 1105篇 |
中国医学 | 108篇 |
肿瘤学 | 1268篇 |
出版年
2023年 | 69篇 |
2022年 | 53篇 |
2021年 | 370篇 |
2020年 | 225篇 |
2019年 | 330篇 |
2018年 | 427篇 |
2017年 | 292篇 |
2016年 | 296篇 |
2015年 | 469篇 |
2014年 | 598篇 |
2013年 | 754篇 |
2012年 | 1116篇 |
2011年 | 1099篇 |
2010年 | 726篇 |
2009年 | 590篇 |
2008年 | 882篇 |
2007年 | 917篇 |
2006年 | 814篇 |
2005年 | 833篇 |
2004年 | 706篇 |
2003年 | 583篇 |
2002年 | 544篇 |
2001年 | 471篇 |
2000年 | 415篇 |
1999年 | 349篇 |
1998年 | 135篇 |
1997年 | 96篇 |
1996年 | 84篇 |
1995年 | 77篇 |
1994年 | 80篇 |
1993年 | 56篇 |
1992年 | 180篇 |
1991年 | 177篇 |
1990年 | 149篇 |
1989年 | 130篇 |
1988年 | 120篇 |
1987年 | 128篇 |
1986年 | 113篇 |
1985年 | 91篇 |
1984年 | 82篇 |
1983年 | 71篇 |
1980年 | 47篇 |
1979年 | 60篇 |
1978年 | 53篇 |
1977年 | 44篇 |
1976年 | 46篇 |
1975年 | 41篇 |
1974年 | 47篇 |
1972年 | 61篇 |
1971年 | 37篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
Chian-Sem Chua Kuo-Ching Yang Jui-Hao Chen Yuh-Hwa Liu Yi-Hsin Hsu 《International journal of food sciences and nutrition》2016,67(2):177-183
Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p?=?0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy. 相似文献
32.
33.
This study aimed to evaluate the effects of dioscorins isolated from 2 yam species, Dioscorea alata (Da-dioscorins) and Dioscorea japonica (Dj-dioscorins), on mouse immune activities. Results from cytokine array indicated that Dj-dioscorins increased the production of tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-3, IL-6, IL-10, IL-12p40, IL-13, monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T cell expressed and secreted (RANTES), and granulocyte colony-stimulating factor (GCSF) in the spleen cells of BALB/c mice. In RAW264.7 macrophage, Da-dioscorins upregulated the expression of TNF-α, IL-1β, IL-6, IL-10, RANTES, MCP-1, and GCSF genes to a greater extent than Dj-dioscorins did. TNF-α, IL-1β, IL-6, IL-10, and RANTES gene expression was higher in spleen cells than in bone marrow and thymus cells in Da-dioscorin- or Dj-dioscorin-treated BALB/c and C57BL/6. Overall, our results suggest that dioscorins exert distinct immunomodulatory effects on mouse immune cells, and that different mouse strains respond differently to dioscorins. 相似文献
34.
35.
36.
37.
38.
Wei-Fan Hsu Po-Heng Chuang Cheng-Kuo Chen Hung-Wei Wang Ming-Hung Tsai Wen-Pang Su Hung-Yao Chen Chi-Ying Yang Chun-Che Lin Guan-Tarn Huang Jaw-Town Lin Hsueh-Chou Lai Cheng-Yuan Peng 《American journal of cancer research》2020,10(12):4547
Real-world predictors of the treatment efficacy of immune checkpoint inhibitors for hepatocellular carcinoma (HCC) are unknown. This retrospective study enrolled 87 consecutive patients with unresectable HCC from May 2017 to December 2019 at two hospitals. Of the 87 patients, 7, 9, 60, and 11 patients had Barcelona Clinic Liver Cancer stages A, B, C, and D, respectively, and 45, 30, and 10 patients were Child-Pugh class A, B, and C, respectively. The median injection numbers of nivolumab and treatment duration were 6 (3-8) and 2.53 (1.47-4.23) months, respectively, and 64.4% of patients received combination therapy. Radiological imaging was not assessed for 25 patients. Objective response (OR) and disease control rates were 19.5% and 39.1%, respectively. A single tumor (odds ratio: 9.542, P = .015) and ≥20% decline in serum α-fetoprotein protein (AFP) levels within the first 3 months of treatment (defined as AFP response, odds ratio: 5.997, P = .042) were predictors of OR. Lack of macrovascular invasion, combination therapy, and AFP response were predictors of progression-free survival. A Cancer of the Liver Italian Program (CLIP) score of 0-2 (hazard ratio [HR]: 3.717, P = .004) and grade 1-2 immune-related adverse events (irAEs, HR: 2.217, P = .049) were predictors of overall survival (OS) in the entire cohort, and a CLIP score of 0-2 (HR: 3.257, P = .009) was a predictor of OS in evaluable patients. IrAEs ≥ grade 3 were noted in 14 patients, and three died as a result. Having a single tumor and AFP response were predictors of OR, and CLIP score was a predictor of OS. 相似文献
39.
Thomas W. Lycan DO MHS Fang-Chi Hsu PhD Christine S. Ahn MD Alexandra Thomas MD Francis O. Walker MD Omar P. Sangueza MD Yusuke Shiozawa MD PhD Sun Hee Park PhD Christopher M. Peters PhD Edgar Alfonso Romero-Sandoval MD Susan A. Melin MD Steven Sorscher MD Katherine Ansley MD Glenn J. Lesser MD Michael S. Cartwright MD Roy E. Strowd MD 《Muscle & nerve》2020,61(5):587-594
40.
Hsien-Chi Liao Jen-Hao Chuang Hsao-Hsun Hsu Ke-Cheng Chen Jin-Shing Chen 《Surgical endoscopy》2020,34(4):1641-1647
Thoracic empyema in uremic patients on maintenance hemodialysis is a challenging situation. The clinical characteristics are rarely reported, and the surgical outcomes remain unclear. We report our experience with video-assisted thoracoscopic surgery in these patients during 10-year period of time. Between 2005 and 2015, we retrospectively reviewed the clinical characteristics, bacteriological studies, and thoracoscopic surgical results of 23 empyema patients undergoing maintenance hemodialysis. The mean patient age was 67.1 ± 12.9 years. All patients had additional preexisting systemic diseases. The mean duration of hemodialysis was 34.7 ± 25.8 months. The infections causing empyema were pneumonia in 11 (47.8%), blood stream infection in 8 (34.8%), and uremic pleuritis in 4 (17.4%). Among the 22 identified microorganisms, the most common pathogen was methicillin-resistant Staphylococcus aureus (31.8%). After thoracoscopic surgery, 8 patients (34.8%) required additional procedures for complications, including 2 patients who required repeated thoracoscopy for hemothorax and 6 (26.1%) patients who required open drainage for residual empyema. The mean hospital stay was 62.4 days, and 6 patients (26.1%) died in the hospital. Univariate and multivariate analyses revealed that maintenance hemodialysis longer than 5 years was a significant factor associated with in-hospital mortality (odds ratio: 14.8, 95% confidence interval 1.5–151.6; p < 0.0001). While surgical management of thoracic empyema in uremic patients undergoing maintenance hemodialysis is associated with high rates of complication and mortality, thoracoscopic surgery is feasible, especially for patients undergoing hemodialysis for less than 5 years. 相似文献